(Bioinspired Photonics-Optofluidics-Electronics Technology and Science)
The BioPOETS group focuses on fundamental bionanoscience, organogenesis,and preventive personalized medicine for global healthcare. In order to establish a quantum nanobiology, we have created nanosatellites and photonic gene circuits that allow molecular imaging and a remote spatiotemporal control of gene regulation in living cells. Also the BioPOETS have been developing the BASICs (Biologic Application Specific Integrated Circuits) for the digitalization of quantitative biology, organ-on-chip, and integrative molecular diagnostics.
The purpose of BioPOETS is to create Bionanoscience for Innovative Healthcare Research and Technology (BIGHEART) that can cultivate inspiration in discovery science, comprehend biological function and mechanism at the nanoscale level, find real-world solutions for the treatment and preventive diagnosis of diseases, and generate health and wealth for the local community and global world.
The BioPOETS will:
Encourage the convergence of life sciences, physical sciences, engineering, computational science, art, and medicine for new scientific discovery and solving healthcare problems by breaking down traditional barriers and maximizing interaction and enhanced collaborations.
Explore to obtain snapshots of what we metaphorically refer to as the cellular galaxy in living cells by creating unprecedented nanosatellites that have triple functions: targeting, imaging, and controls of optical gene regulations. The nanosatellites with the function of PRET nanospectroscopy will be applied to monitor the electron transfer dynamics of biomolecules in living cells.
Elucidate the intracellular signaling pathways in living cells; the mechanism of the intra- and extracellular signaling networks; how cells communicate, differentiate, and organize to form unique biological systems with extraordinary physiological functions; the in vitro organogenesis: organ formation, organ function, and organ diseases on chip.
Establish quantum nanobiology for photonic gene circuits and groundbreaking molecular diagnostic methods including Light-based In Vivo Evaluation of DNA (“LIVE-DNA”), which will unite customized DNA binding proteins and nanosatellites to allow in vivo imaging of DNA mutations. Developing the capability to detect DNA-based alterations in living cells would have dramatic impacts on the treatment and diagnosis of human diseases as well as on basic biomedical science to answer fundamental questions of human biology.